
Scientific Research and Clinical Studies
The Osato Research Institute (ORI) is a non-profit organization founded in 2004 and based in Gifu, Japan. ORI conducts and coordinates scientific programs and clinical studies that focus on our natural defence systems, healthy living, healthy aging, and Osato ‘fermented papaya preparation’ or FPP®.
World-renowned scientists study the properties of FPP® and, as members of the scientific committee, have contributed to the scientific proof of the effects of the FPP®.
The members of the scientific committee come from different fields and many different countries. They present the results of their research on FPP® at international academic conferences, at meetings of the scientific committee of ORI, and in scientific journals.
Below we present the main research and studies that have been conducted on FPP®.
International scientific recognition – what scientists say about FPP®
“FPP® has remarkable properties to combat oxidative stress and to stimulate the immune system.”
Prof. Luc Montagnier
Immunologist
President of the World AIDS foundation
2008 Nobel Prize of Medicine
“We studied FPP® at the University of Southern California in our laboratories and demonstrated its antioxidant properties, but also a very important action of improving the immune system.”
Prof. Lester Packer
University of Southern California Health Center, PhD
“Papaya is rich in antioxidants and we recently know the importance of the protection provided by antioxidants in our body. We compared five different fruits and two vegetables and found papaya to be the most antioxidant-rich tropical fruit.”
Dr. Mark E. Weksler
Professor Emeritus of Medicine, Weill Cornell Medical College
“In a preliminary study, on 12 patients suffering from thalassemia, the FPP® by its antioxidant action allowed a decrease in oxygenated free radicals as well as an increase in the level of glutathione in both red blood cells and platelets.”
Dr. Eliezer Rachmilewitz
Hebrew University Medical Center – Jerusalem
Scientific studies
Studies related to immunity:
- Actions of FPP® on the cells of the immune system | Prof. Lester Packer | ISBN 2-7046-1675-2
- Nitric oxide synthesis and TNF-secretion in RAW 264.7 macrophages | G. Rimbach & co | PMID: 12659174
- Effects of dietary supplement on IFN producing capacity in humans |A, Kishi Kishida & co | ISSN: 0197-8357
- Advantages of Fermented Papaya on our health: Beneficial effects on oxidative stress and immunity: oxidative stress and chronic diseases | Prof. Luc Montagnier | ISBN 2-7046-1675-2
Studies related to antioxidants:
- Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on redox status and DNA damage in healthy elderly individuals and relationship with GSTM1 genotype. A randomized, placebo-controlled, cross-over study. | F. Marotta & Co | PMID: 16804018
- Advantages of Fermented Papaya on our health: Beneficial effects on oxidative stress and immunity: oxidative stress and chronic diseases. | Prof. Luc Montagnier | ISBN 2-7046-1675-2
- Free radical regulatory and immunomodulatory effects of bio-normalizer (FPP®) | Osato J.A. & co | ISBN: 0-935315-64-0
- Free radical scavenging action of bio-catalyzer No.11 (FPP®) and its by-product | Santiago L.A. & co | PMID:1665836
- Effect of quality-controlled fermented nutraceuticals on skin aging markers: a double-blind, antioxidant-controlled study | G. Bertuccelli & co I PMID: 26998011 | https://pubmed.ncbi.nlm.nih.gov/26998011/
Studies related to cellular energy:
- Does oral supplementation of a Fermented Papaya Preparation correct respiratory burst function of innate immune cells in type 2 diabetes mellitus patients? | Ryan Dickerson & co | PMID:25268638
Clinical studies
Clinical study related to the respiratory tract:
References: Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? F. MAROTTA & Co | PMID:22824755
Clinical study of oxidative stress in Alzheimer’s and Parkinson’s disease:
References: Oxidative stress in patients with Alzheimer’s disease: Effect of extracts of fermented papaya powder. BARBAGALLO & Co | Hindawi Publishing Corporation, Mediators of Inflammation, Article ID 624801
Clinical study of cardiovascular diseases:
References: Cardioprotective effect of a bio fermented nutraceutical on endothelial function in healthy middle-aged subjects.
F. MAROTTA & Co | PMID:22533427
Clinical study of skin aging:
References: Testing a quality-controlled fermented nutraceutical on skin aging markers: an antioxidant controlled, double-blind study
N. ZERBINATI & Co | PMID:26998011
Clinical study of chronic wound infection in patients with type II diabetes:
References: Does oral supplementation of a fermented papaya preparation correct respiratory burst function of innate immune cells in type 2 diabetes mellitus patients?
Ryan Dickerson & Co | PMID:25268638
May dietary supplementation augment respiratory burst in wound-site inflammatory Cells? | A. DAS & Co | PMID:28810801
Clinical study of electromagnetic field intolerance syndrome (EMFIS):
References: Phase I-II study testing the therapeutic effect and stimulating properties of antioxidant defences to patients suffering of Electromagnetic Fields Intolerance Syndrome. D. BELPOMME & Co | Functional Foods in Health and Disease 2018; 8(2): 122-144
US Patent No.US10993980B2 – “Method for Treating Electrohypersensitivity with FPP®”
Sport & FPP®
FPP® is also an effective ally when exercising and a good support during and after intense sports activities.

Certified by Informed Sport that it is not doping for professional athletes.
Made by Osato International Inc. I #1956 Inatomi Ono-cho Ibi-gun I Gifu 501 0501 JAPAN
Distributed in Croatia by Maay d.o.o., Mlinovi 159a, Zagreb, Hrvatska, OIB:36025813831
FPP® is not intended to treat, cure, or prevent any disease.